Archives of Pharmacal Research
- Volume 20 Issue 3
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- Pages.288-290
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
An Efficient Synthesis of 3-(E)-Hydroxypropenyl Cephem Derivatives, Key intermediates for 3-(E)-Ammoniopro-penylcephalosporing Antibiotics
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Lee, Yong-Sup
(Division of Applied Science, Korea Institute of Science and Technology)
;
- Lee, Jae-Yeol (Division of Applied Science, Korea Institute of Science and Technology) ;
- Jeong, Jin-Hyun (Division of Applied Science, Korea Institute of Science and Technology) ;
- Park, Hokoon (Division of Applied Science, Korea Institute of Science and Technology)
- Published : 1997.06.01
Abstract
An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achieved via Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.