Archives of Pharmacal Research
- Volume 20 Issue 3
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- Pages.264-268
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives
- Cho, Won-Jea (College of Pharmacy, Chonnam National University) ;
- Yoo, Su-Jeong (College of Pharmacy, Chonnam National University) ;
- Park, Myun-Ji (College of Pharmacy, Chonnam National University) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University) ;
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Lee, Chong-Ock
(Screening Center, Korea Research Institute of Chemical Technology)
- Published : 1997.06.01
Abstract
In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.