한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제7권1호
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- Pages.40-44
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- 1997
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
오메프라졸과 란소프라졸의 혼합으로 인한 헤리코박터파이로리에 대한 항생제의 감수성 변화
The Effect of Omeprazole and Lansoprazole on the Susceptibility of Helicobacter pylori to Antimicrobial Agents
- 방성혜 (숙명여자대학교 약학대학) ;
-
이숙향
(숙명여자대학교 약학대학) ;
- 서옥경 (숙명여자대학교 약학대학) ;
-
신현택
(숙명여자대학교 약학대학) ;
- 조경주 (경희대학교 문리과대학) ;
- 이호근 (경희대학교 문리과대학)
- Bang, Sung Hye (College of Pharmacy, Sookmyung Women's University) ;
-
Lee, Suk Hyang
(College of Pharmacy, Sookmyung Women's University) ;
- Suh, Ok Kyung (College of Pharmacy, Sookmyung Women's University) ;
-
Shin, Hyun Taek
(College of Pharmacy, Sookmyung Women's University) ;
- Cho, Kyung Joo (Department of Biology, Kyunghee University) ;
- Rhie, Ho Gun (Department of Biology, Kyunghee University)
- 발행 : 1997.05.01
초록
Helicobacter pylori(HP) has been implicated as the cause of acute and chronic gastritis, peptic ulcer, and gastric carcinoma. To date the most successful treatment in eradicating HP is known to be the combination of two or more antibiotics with an anti-ulcer drug. In this study, in vitro antimicrobial activity against two was assessed, when proton pump inhibitors (PPIs), omeprazole and lansoprazole, were added to antibiotics at different concentrations. The assays in the absence of PPIs gave minimum inhibitory concentration(MIC) value of 0.63 mg/l for amoxicillin, 4 mg/l for tetracycline, 0.08 mg/l for clarithromycin and 0.16 mg/l for azithromycin. At the concentrations of 125 mg/l, 25 mg/1 and 0.5 mg/l of omeprazole, and the concentrations of 31.25 mg/l, 6.25 mg/l and 1 mg/l of lansoprazole, the MICs of clarithromycin and azithromycin were reduced by
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