Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 7 Issue 1
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- Pages.33-39
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- 1997
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Cardioprotective and Antihypertensive Effects of KR-31281, KR-31282 and KR-31299, Newly Synthesized $K_{ATP}$ Openers, in Conscious Rats and Isolated Ischemic Rat Hearts
신규 합성 $K_{ATP}$ 통로 개방제인 KR-31281, KR-31282 및 KR-31299의 흰쥐 적출 허혈 심장 및 비마취 흰쥐에 대한 심장보호 및 혈압강하 작용
- Lee, Sun-Sook (College of Pharmacy, Chungbuk National University) ;
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Yun, Yeo-Pyo
(College of Pharmacy, Chungbuk National University) ;
- Shin, Hwa-Sup (Screening & Toxicology Center, Korea Research Insitute of Chemical Technology)
- Published : 1997.05.01
Abstract
Cardiac and antihypertensive effects of BMS-180448, a cardiac-selective ATP-sensitive potassium channel opener, and its newly synthesized derivatives KR-31281, KR-31282 and KR-31299 were evaluated in isolated perfused rat hearts (25 min global ischemia/30 min reperfusion) and conscious rats. Three new compounds
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