랫트에 인공감염된 간질(Fasciola hepatica)에 미치는 closantel의 구충효과

Efficacy of closantel against Fasciola hepatica in experimentally-infected rats

Male and female Sprague-Dawley rats 8 weeks of age were inoculated per os with 10 Fasciola hepatica metacercariae each. After the infection was verified by fecal examination, they were divided into four groups at 14 weeks post-inoculation; three groups were dosed orally at 10, 20 and 30mg/kg of closantel($Flukiver^{TM}$), a salicylanilide compound and the rest used as untreated control. Efficacy of closantel was monitored weekly by fecal examination of all infected animals starting during the second week post-treatment(PT) and continuing for three weeks. Closantel elicited 96.0, 86.9 and 87.4% efficacy in rats treated with 10mg/kg at the second, third and fourth week PT, respectively. It elicited a 100% efficacy in rats treated with 20 and 30mg/kg.