Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
권호 표지

A Mechanism of Gastric Antiulceration by the Extract of Artemisiae asiatica

애엽 추출물의 항위궤양에 대한 기전

  • Published : 1997.12.29
Download PDF
⟨ Previous Next ⟩

Abstract

In oriental medicine, Artemisiae asiatica (AA) has been used as analgesic, antiinflammatory agent, and coagulatory agent. Furthermore, eupatilin, a kind of flavonoids, is known as the active principle component of AA. This study was undertaken to determine the gastric antiulceration of AA and to elucidate its mechanism. AA showed the inhibitory effect on gastric ulceration induced by EtOH/HCl and aspirin. To elucidate its mechanism, the effect of AA on lipidperoxide level in gastric mucosa, microsome lipidperoxidation, iron -dependent lipidperoxidation, and neutrophil activation were examined. It is suggested that the antiperoxidative and antineutrophil activity of AA play important roles as a possible mechanism. These results suggest that AA might have gastric antiulceration activity due to antilipidperoxdative and antineutrophil activity.

Keywords

References

  1. Gastroenterelogy v.96 Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use Fries, J. F.;Miller, S. R.;Spitz, B.W.
  2. Biochem. Pharmacol. v.39 Prostacyclin and betaprost sodium as suppressors of activated rat polymorphonuclear leukocytes Kainoh, M.;Nishio, S.
  3. Free Rad. Comm. v.7 Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats Yoshikawa, T.;Ueda, S.;Naito, Y.;Takahashi, S.; Oyamada, H.; Morita, Y.;Yoneta, T.;Kondo, M.
  4. Gastroenterology v.9 Role of oxygen radicals in ischemia-induced. lesions in the rat stomach Perry, M.A.;Wadhwa, S.;Parks, D.A.;Pickard, W.;Granger, D.N.
  5. Dig. Dis, Sci v.32 Free radicals and lipid peroxidation in ethanol a aspirin-induced gastric mucosal injury Piham, G.;Regillo, C.;Szabo, S.
  6. Arzneim-Forsch v.43 Investigations of Indomethacin- induced Gastric Ulcer in Rats Kapui, J.;Boer,K.;Rozsa,I.;Blasko, K.;Hermecz, I.
  7. Gastroenterology v.100 A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit Wallace, J.L.;Arfors, K.E.;Mcknight,W.
  8. Arch. Biochem. Biophys. v.280 Inhibition of Stress-induced Gastric Mucosal Injury by a long Acting Superoxide Dismutase that circulate Bound to Albumin Masahiko Hirota;Masayasu Inoue;Yukio Ando;Yoshimasa Morino
  9. 生藥大事典 鄭普燮
  10. Biochemistry v.20 Characteristics of the co-factor requirements for the superoxide-generating NADPH-oxidase of human polymorpho nuclear leukocytes Light, D.R.;Walsh, C.;O'callagham,A.M.;Goetzl, E. L.;Tauber,A,I.
  11. Blood v.60 Relation of human Neutrophil phorbolester Receptor occupancy and NADPH- oxidase activity Alfred, I. Tauba;Doreen, B. Brettler;Peter, M. Blumberg
  12. J. Clin. Invest. v.68 Receptor-mediated Regulation of superoxide production in human neutrophils stimulated by phorbol Myristate Acetate Robert, I. Lehrer;Lenore Cohen
  13. Digestion v.49 Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats Takeuchi, K.;Ueshima, K.;Hironaka, Y.;Fujioka, Y.;Matsumoto, J;Okabe, S.
  14. Digestion v.43 Role of Oxygen-Derived Free Radicals in the Mechanism of Chronic Gastric Ulceration in the Ret: Implications for Cytoproctection Salim, A.S.
  15. Arch. Biochem. Biophys. v.280 Inhibition of stress-induced gastric mucosal injury by a long acting superoxide dismutase that circulates bound to albumin Hirota, M.;Inoue M.;Ando, Y.;Morino, Y.
  16. J. Clin. Gastroenterol. v.12 The Role of Endogenous Free Radical Scavenger on Tissue Recovery in the Experimental Ulcer Model Oshima, A,; Asayama, K.; Sakai, N.;Kitajima, M.
  17. Gut. v.33 Mucosal reactive oxygen metabolite production in duodenal ulcer disease Davies, G.R.;Simmonds, N.J.;Stervens, T.R.;Grandison, K.;Blake, D.R.; Rampton, D.S.
  18. J. Physiol. v.259 Gastric ulceration induced by nonsteroidal anti- inflammatory drugs is a neutrophil-dependent process Wallace, J.L.;Keenan, C.M.;Granger,D.N.
  19. Blood v.58 Leukotriene B$_4$ is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence Pamblad, J.;Malmsten, C.L.;Uden, A.M.;Radmark, O.;Engstedt, L.;Samulesson, B.
  20. Acta physiol, Scand. v.110 Leukotriene $B_4$; a highly potent and stereospecific factor stimulating migration of polymorphonuclear leukocytes Malmsten, C. L.;Palmblad, J.;Uden,A.M.;Radmark,O.;Engstedt, L.;Samulesson, B.
  21. TIPS v.13 Pathogenesis of NSAID gastropathy: are neutrophils the culprits? Wallace, J. L;Granger,D.N.
  22. Planta Med. Inhibition of mast cells histamine release by flavonoids and bioflavonoids Amellal, M.;Bronner, C.;Briancon, F.;Haag, M.;Anton, R.;Landry, Y.
  23. J. Nat. Prod. v.53 Natural Products as a source of potential cancer chemotherapeutic and chemopreventive agents Cassady, J.M.;Baird, W.M.;Chang, C.J.
  24. Economic and Medicinal plant Research v.5 Plants as a sources of potential antiviral agents Che, C.T.
  25. J. Nat. Prod. v.55 Inhibitory effect of flavonoids on moloney murine leukemia virus reverse transcriptase activity Chu, S.C.;Hsieh, Y.S.;Lin, J.Y.
  26. Plant Flavonoids in Biology and Medicine. v.213 Antiinflammatory and antiallergic properties of flavonoids Gabor, M.
  27. Biochem. Pharmacol. v.43 Effects of flavonoids on immune response and inflammatory cell functions Middleton, E.;Kandaswami, C.
  28. Plant Flavonoids in Biology and Medicine Ⅱ Flavonoids and arachidonic acid metabolism Welton, A.F.;Hurley, J.;Will, P.
  29. Biochem. Pharmacol. v.39 Induction of mammalian topoisomerase Ⅱ dependent DNA cleavage by noninterclative flavonoids, genestein and orobol Yamashita, Y.;Kawada, S.Z.;Nakano, H.
  30. Biochem. Biophys. Res. commmun. v.157 Effect of genistein on topoisomerase activity and on the growth of Ha-ra-transformed NIH 3T3 cells Okura, A.;Arakawa, H.;Oka, H.;Yoshinari, T.;Monden, Y.
  31. Am. J. Physiol. v.251 Xanthine oxidase and neutrophil infiltration in intestinal ischemia Grisham, M.B.;Hernandez, L.A.;Granger, D.N.
  32. Gastroenterology v.90 Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the rat intestine Granger, D.N.;McCord, J.M.;Panks, D.A.;Hallmarth, M.E.
  33. Biochem. Pharmacol. v.36 Prostacyclin and iloprost on generation of superoxide anions by human PMN stimulated by zymosan or FMLP Gryglewski，R.J.;Szezeklik, A.;Wandzilak, M.
  34. Federation Proc. v.40 Superoxide dismutase prevents increased lung vascular permeability after air emboli in anesthetized sheep Flick, M.R;Hoeffel, J.;Staub, N.C.
  35. Federaion Proc. v.46 Extracellular release of superoxidc and hydrogen peroxide by vascular endothelium Freeman, B.A.;Cunningham, M.K;Panus, P.C.
  36. Federation Proc. v.46 Superoxide anion release by pulmonary endothelium: response to phorbol ester and Ca inophore Selvaraj, P.M.;Goodwin, J.D.;Ryan, U.S.
  37. J. Pharmacol Exp. Ther. v.245 Interaction of neutrophils with vascular smooth muscle: identification of a neutrophil-derived relaxing factor Rimele, T.J.;Strum, R.J.;Adams, L.M.
  38. J. Cell Biol. v.97 Subecellular localization of the b-cytochrome component of the human netrophil microbicidal oxidase: translocation during activation Borregaard, N.;Clark, R.
  39. J. Pharm. Pharmacol. v.45 Role of Polymorphonuclear leucocytes and oxygen derived free radicals in the formation of gastric lesions induced by HCl/ethanol, and a possible mechanism of protection by antiulcer polysaccharide Mattsumoto, T.;Moriguchi, T.;Yamada, H.
  40. J. Biol. Chem. v.261 The Involvement of Iron in Lipid Peroxidation Braughler, J.M.;Duncan, L.A.;Chsae, L.A.
  41. J. Biol. Chem. v.261 Inhibitory effect of prostaglandin $E_2$, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils Takenawa, T.;Ishitoya, J.;Nagai, Y.
  42. J. of Immunology v.129 Mechanism of the Luminol dependent Chemiluminescence of Human Neutrophils Lawrence, R, Frederick, W.;Henderson, S.
  43. Lipids v.15 Coloring condition of thiobarbituric acid test for detecting lipid peroxides Asakawa, T.;Matsushita, S.
  44. Methods in Emzymol v.92 Microsomal Lipid Peroxidation Ernster, L.;Nordenbband, K.
  45. Methods in Emzymol. v.30 Microsomal Lipid Peroxidation Buege, J.A.;Aust, J.