An Experimental Study on the Effect of Soojeomsan(Shou Nian San) on CPK and Na-K ATPase of Ischemic and Perfused Rat Heart

수념산(手拈散)이 허혈성(虛血性) 심장(心臟)의 심근(心筋) 효소(酵素)에 미치는 영향(影響)

  • Kang, Kwan-Ho (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Moon, Sang-Kwan (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Ki-Ho (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Young-Suk (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Bae, Hyung-Sup (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung-Sup (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 강관호 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 이경섭 (경희대학교 한의과대학 심계내과학교실)
  • Published : 1997.12.30

Abstract

Background The stenosis of the coronary artery may decrease myocardial oxygen supply and occur myocardial ischemia or infarction. Soojeomsan, one of analgesics is generally regarded to have the effect of vitalizing blood, expelling blood stasis and alleviation cardiac pain. Methods The purpose of this experimental study is to find the influence of Soojeomsan on cardiac enzyme (CPK, Na-K ATPase) of ischemic and reperfused rat hearts which are isolated under the Langendorff apparatus. Ischemia was induced In isolated hearts of Sprague-Dawley rats by ceasing the perfusion for 20 minutes. The experiments were divided into a normal saline orally administered group(control group), a Soojeomsan orally 20ml administered group(sample A) and a Soojeomsan orally 30ml administered group(sample B). The CPK (creatinine phosphokinase) and Na-K ATPase activity of this three group were measured and compared in order to assess the influence of Soojeomsan on protection of isolated rat hearts from ischemia. Results 1. CPK was significantly reduced in Sample A group and Sample B group in comparison with control group in reperfusion(P<0.01), and there were no significant difference between Sample A and B. 2. Na-K ATPase activity was significantly increased in Sample A group and Sample B group in comparison with control group in ischemia(P<0.001), and the activity was significantly higher in Sample B then in Sample A.(P<0.01) 3. There were no significant difference in Na-K ATPase activity of the three groups after reperfusion. Conclusion Soojeomsan has effects to decrease CPK activity and activate Na pump. This result in protection of the myocardium of isolated rat hearts from ischemia.

Keywords

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