대한한의학회지 (The Journal of Korean Medicine)

  • 제18권2호
  • /
  • Pages.15-32
  • /
  • 1997
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

희렴이 가토(家兎)의 혈관내피세포성(血管內皮細胞性) 이완인자(弛緩因子)에 미치는 영향(影響)

The Effects of Siegesbeckiae Herba on EDRF in the Carotid Artery of the Rabbit

  • 김호현 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실)
  • Kim, Ho-Hyun (Dept. of Physiology, College of Oriental Medicine, Dong-Guk Univ.) ;
  • Kim, Gil-Whon (Dept. of Physiology, College of Oriental Medicine, Dong-Guk Univ.)
  • 발행 : 1997.10.30
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초록

This study was undertaken to define the mechanism of Siegesbeckiae Herba-induced relaxation in rabbit common carotid artery contracted by agonists. In order to investigate the effect of Siegesbeckiae Herba on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Siegesbeckiae Herba-induced relaxation, Siegesbeckiae Herba extract infused into contracted arterial strips induced by agonists after treatment of lanthanum chloride, indomethacin, atropine, $N\omega-nitro-{_L}-arginine$, cobalt chloride or methylene blue. The relaxation effect of Siegesbeckiae Herba was dependent on the presence of endothelium, showing that Siegesbeckiae Herba-induced relaxation was not observed in the strips without endothelium. The endothelium-dependent relaxation induced by Siegesbeckiae Herba was suppressed by the pretreatment of lanthanum chloride, $N\omega-nitro-{_L}-arginine$, cobalt chloride or methylene blue, but it was not observed in the strips pretreated with indomethacin or atropine. These results demonstrated that Siegesbeckiae Herba may inhibit agonist-induced contraction through an increase in the cyclic GMP by the production of nitric oxide in the vascular endothelial cells.

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참고문헌

  1. 精校黃帝內經素問 洪元植
  2. 臟腑辨證論治 金完熙;崔達永
  3. 高血壓 趙光勝
  4. 現代中醫內科學 何紹奇
  5. 심장학 서울대학교 의과대학
  6. Arterial Hypertension v.5 Gross, F.;Robertson, J. I. S.
  7. 本草學 康秉秀;金永坂
  8. 中藥學 高學敏
  9. 本草從新 吳儀洛
  10. 本草求眞 黃宮繡
  11. 中藥藥理與應用 王浴生
  12. 高血壓에 豨薟丸과 Hydralazine, Atenolol, Nifedipine 및 Furosemide의 倂用投與에 關한 實驗的 硏究 高昌男
  13. 豨蘞의 藥理學的 硏究 沈在錄
  14. 희첨이 실험적 고지혈증의 예방과 치료효과에 미치는 영향 장동순
  15. 東醫生理學會誌 v.10 no.1 豨薟이 收縮된 血管에 미치는 影響 金昊顯;申興黙;金吉萱
  16. 大韓韓醫學會誌 v.3 no.2 高血壓治療의 辨證에 關한 硏究 金完熙
  17. 臟象槪說 盛增秀;王琦
  18. 藥品植物學各論 韓德龍
  19. 생명의 이치 血液$\cdot$心臟$\cdot$循環 金祐謙
  20. Medical Physiology v.20 Guyton, A. C.
  21. 약리학강의 李宇柱;洪思奭
  22. Am. J. Physiol. v.263 EDRF plays central role in collateral flow after arterial occlusion in rabbit ear Randall, M. D.;Griffith, T. M.
  23. Br. J. Pharmacol. v.108 no.3 The effect of NG-nitro-$_L$-arginine methyl ester upon basal blood flow and endothelium-dependent vasodilatation in the dog hindlimb White, D. G.;Drew, G. M.;Gurden, J. M.;Penny, D. M.;Roach, A. G.;Watts, I. S.
  24. Nature v.327 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Palmer, R. M. J.;Ferrige, A. G.;Monacada, S.
  25. Circ. Res. v.52 no.3 Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP Rapoport, R. M.;Murad, F.
  26. J. Physiol. v.351 Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric arery Bolton, T. B.;Lang, R. J.;Takewaki, T.
  27. Br. J. Pharmacol. v.93 no.3 Endothelium-dependent hyperpolarization of canine coronary smooth muscle Feletou, M.;Vanhoutte, P. M.
  28. Jpn. J. Physiol. v.42 no.2 Nitroarginine-sensitive and -insensitive components of the endothelium-dependent relaxation in the guinea-pig carotid artery Suzuki, H.;Chen, G.;Yamamoto, Y.;Miwa, K.
  29. Biochemistry Voet, D.;Voet, J. G.
  30. Circulation v.72 no.4 Platelets, endothelium, and vasospasm Vanhoutte, P. M.;Houston, D. S.
  31. Ann. Rev. Physiol. v.48 Modulation of vascular smooth muscle contraction by the endothelium Vanhoutte, P. M.;Rubanyi, G. M.;Miller, V. M.;Houston, D. S.
  32. Circ. Res. v.65 no.1 Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein Ignarro, L. J.
  33. Circ. Res. v.64 no.2 Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness ot formation of endothelium-derived nitric oxide in pulmonary artery and vein Ignarro, L. J.;Gold, M. E.;Buga, G. M.;Byrns, R. E.;Wood, K. S.;Chaudhuri, G.;Frank, G.
  34. J. Cardiothorac. Vasc. Anesth. v.5 no.1 Endothelium-derived relaxing factor ; Basic review and clinical implications Johns, R. A.
  35. Biochem. Biophys. Res. Commun. v.153 no.3 L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation Palmer, R. M.;Rees, D. D.;Ashton, D. S.;Moncada, S.
  36. FASEB J. v.3 no.9 Endothelium-derived relaxing and contracting factors Furchgott, R. F.;Vanhoutte, P. M.
  37. 大韓韓醫學會誌 v.11 no.2 風의 生理學的 認識 黃寅秀
  38. 黃帝內經素問譯解 楊維傑
  39. 黃帝內經素問集注 張隱庵
  40. Proc. Natl. Acad. Ssl. v.88 no.5 Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells Forstermann, U.;Pollock, J. S.;Schmidt, H. H. H. W.;Heller, M.;Murad, F.
  41. Pfl$\ v.348 no.1 Relative contributions of $Ca^{2+}$ influx and cellular $Ca^{2+}$ release during drug induced activation of the rabbit aorta Deth, R.;Breemen, C. van
  42. Biochem. Biophys. Res. Commun. v.191 no.3 The passive clacium leak in cultured porcine aortic endothelial cells Demirel, E.;Laskey, R. E.;Purkerson, S.;Breemen, C.
  43. Br. J. Pharmac. v.79 Endotherium-dependent relaxation of the pig aorta ; relationship to stimulation of 86Rb efflux from isolated edotheial cells Gordon, J. L.;Martin, W.
  44. Am. J. Physiol v.264 Endothelium-derived relaxing factor inhibits norepinephrine contraction of fetal guinea pig arteries Thompson, L. P.;Weiner, C. P.
  45. Nature v.288 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Furchgott, R. F.;Zawadzki, J. V.
  46. The Journal of Pharmacology and Experimental Therapeutics v.237 Activation of purified soluble guanylate cyclase by endothelium-erived relaxing factor from intrapulmonary artery and vein ; stimulation by acetylcholine, bradykinin and arachidonic acid Ignarro, L. J.;Harbison, R. G.;Wood, K. S.;Kadowitz, P. J.
  47. J. Cardiovasc. Pharmacol. v.22 no.6 Mus-carinic receptor subtypes mediating vaso-delation and vasoconstriction in isolated, perfused simian coronary arteries Ren, L. M.;Nakane, T.;Chiba, S.
  48. Jpn. J. Pharmacol. v.58 no.1 Effects of L-$N^G$-monomethyl arginine on the cyclic GMP formations in rat mesenteric arteries Fukuda, N.;Izumi, Y.;Soma, M.;Watanabe, Y.;Watanabe, M.;Hatano, M.
  49. Br. J. Pharmacol. v.99 no.3 L-$N^G$-monomethyl arginine and L-$N^G$-nitro arginine inhibit non-adenergic, non-cholinergic relaxation of the mouse anococcygeus muscle Gibson, A.;Mirzazadeh, S.;Hobbs, A. J.;Moore, P. K.
  50. Br. J. Pharmacol. v.107 no.2 Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery Crack, P.;Cocks, T.
  51. Br. J. Pharmacol. v.99 no.2 L-$N^G$-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-depenent vasodilatation in vitro Moore, P. K.;al-Swayeh, O. A.;Chong, N. W.;Evans, R. A.;Gibson, A.
  52. J. Cardiovasc. Pharmacol. v.20 no.3 Release of multiple endothelium derived relaxing factors from porcine coronary arteries Myers, P. R.;Guerra, R. Jr.;Harrison, D. G.
  53. Anesthesiology v.77 no.5 Effects of propofol and thiopental in isolated rat aorta and pulmonary artery Park, W. K.;Lynch, C. 3d; Johns, R. A.
  54. 동국의학 v.2 세포외 $Ca^{2+}$와 Ca 길항제들이 내피세포성 이완인자의 분비에 미치는 영향 서석효
  55. 대한흉부외과학회지 v.24 no.3 내피세포성 이완인자에 대한 세포의 $Ca^{++}$ 및 $Ca^{++-}$길항제의 작용기전 진성훈;서경필;서석효;김기환
  56. JPN. J. Pharmacol. v.58 no.SUP.2 The inhibitory effect of $Co^{2+}$ on the relaxing activity of EDRF Suh, S. H.;Kim, S. J.;Hwang, S. I.;Kim, K. W.