Journal of Pharmaceutical Investigation
- 제27권2호
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- Pages.145-151
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- 1997
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
고지혈증 랫트를 이용한 작약의 수종 용매 추출물에 의한 항고지혈 효과
Effect of Several Solvent Extracts from Paeoniae Radix on Experimental Hyperlipidemia in Rats
- 노환성 (울산대학교의과대학) ;
- 고우경 (아산생명과학연구소) ;
- 양현옥 (아산생명과학연구소) ;
- 박건구 (아산생명과학연구소) ;
- 조영환 (아산재단서울중앙병원 약제부) ;
- 박형섭 (울산대학교의과대학)
- Ro, Hwan-Seong (University of Ulsan, college of Medicine) ;
- Ko, Woo-Kyoung (Asan Institute of Life Science) ;
- Yang, Hyun-Ok (Asan Institute of Life Science) ;
- Park, Kun-Koo (Asan Institute of Life Science) ;
- Cho, Young-Hwan (Department of Pharmacy, Asan Meical Center) ;
- Park, Hyoung-Sup (University of Ulsan, college of Medicine)
- 발행 : 1997.06.20
초록
Hexane, chloroform, methanol and water extracts of Paeoniae Radix were tested on the experimentally induced hypercholesterolemia in rats for lowering effect of serum lipoprotein contents. Hyperlipidemia was induced on male Wistar rats by feeding high cholestetrol diet for 7 days. Serum lipid profile was verified on these rats by measuring total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL), and low density lipoprotein cholesterol (LDL). Then, the diet was changed to normal. At the same time, hexane, chloroform, methanol and water extract of Paeoniae Radix were given orally on daily basis, and the changes in the serum lipid profile were assessed for 4 weeks. Methanol extract of Paeoniae radix decreased TC level at 1, 2, and 4 week point significantly, and water extract decreased TC level at 4 week point significantly comparing with the control group.