Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 29 Issue 1
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- Pages.156-160
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- 1997
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- 0367-6293(pISSN)
Screening of Inhibitory Activity of Edible Mushrooms on the Monoamine Oxidase
모노아민 산화효소에 대한 식용버섯류의 저해활성 검색
- Hwang, Keum-Hee (Korea Food Research Institute) ;
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Kim, Hyun-Ku
(Korea Food Research Institute) ;
- Han, Yong-Nam (Natural Product Research Institute, Seoul National University)
- Published : 1997.02.01
Abstract
The monoamine oxidase (MAO, EC 1.4.3.4) plays a central role in the metabolism of many amines including the neurotransmitter monoamines. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline much better than phenethylamine (PEA) or benzylamine (BA), and is preferentially inhibited by clorgyline, whereas MAO-B prefers PEA and BA as substrates and is preferentially inhibited by deprenyl. MAO inhibitors were among the first drugs used in the treatment of depression, and it is known to be the inhibition of MAO-A which is important for the antidepressant effect of MAO inhibitors. For the purpose of evaluating MAO inhibitory activities from natural resources, three kinds of edible mushrooms were screened by tracing the inhibitory activities against rat brain mitochondrial MAO-A, utilizing serotonin as a substrate and rat liver mitochondrial MAO-B utilizing benzylamine as a substrate. Among the tested mushrooms, Ganoderma lucidium and Lentinus edodes showed the weak inhibitory activities against MAO-B.
식용버섯류들의 MAO 저해활성을 검색할 목적으로 몇가지 유기용매를 이용하여 추출분획을 조제하고 이들의 MAO에 대한 저해활성을 검색하였다. 검색된 3종 버섯류의 유기용매 추출물들은 영지버섯 bud의
Keywords
- monoamine oxidase-A;
- monoamine oxidase-B;
- edible mushrooms;
- inhibitory activity;
- Ganoderma lucidium;
- Lentinus edodes