Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Multidrug-resistance Reversing Activity of Medicinal Plants

약용 식물의 암세포 다제내성 조절 활성 검색

  • Kim, Se-Eun (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology) ;
  • Hwang, Bang-Yeon (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Ho (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Choong (College of Pharmacy, Seoul National University) ;
  • Lee, Kyong-Soon (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jung-Joon (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1997.12.30
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Abstract

Methanol extracts from 450 plants were screened for muttidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistant KB-Vl cells. Among them, the extracts of Cynanchum wilfordii, Torilis japonica, Celastrus orbiculatus, Melia toosendan and Teminialia chebula strongly potentiated vinblastine cytotoxicity in KB-Vl cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-Vl cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their ativity solely by cytotoxicity.

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