Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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An 5-Lipoxygenase Inhibitor Isolated from the Roots of Cynanchum wilfordi Hemsley

은조롱뿌리의 5-Lipoxygenase활성 억제성분

  • 이원철 (동국대학교 한의과대학 한의학과) ;
  • 이동웅 (동국대학교 자연과학대학 생화학과)
  • Published : 1997.12.30
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Abstract

The effects of the extract of the root of Cynanchum wilfordi (Asclepiadaceae), the alkaloid fraction, and the isolated main constituent (gagaminine) on 5-lipoxygenase(5-LOEC 1.13.11.34) in bovine PMNL have been studied. The effect of the crude extracts of wildand cultivated plant was also compared each other. Furthermore, the inhibitory effect of gagaminine on 5-Lo was compared with those of the standard drugs. Gagaminine inhibited 5-Lo activity with an $IC_{50}$ value of $26\;{\mu}M$, this result indicates that gagaminine may be useful for in vivo experiments as 5-LO inhibitor.

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