Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-lipid Peroxidation and Liver Protective Effects of Polygonum aviculare L.

마디풀(Polygonum aviculare L.) 성분의 지질과산화억제 및 간보호에 미치는 효과

  • Choi, Hyuck-Jai (East-West Medical Research Institute, Kyung Hee University) ;
  • Kim, Jong-Woo (East-West Medical Research Institute, Kyung Hee University) ;
  • Hong, Nam-Doo (Natural Products Research Institute of Bangchon, Hankooksinyak co. Ltd.) ;
  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University)
  • 최혁재 (경희대학교 동서의학연구소) ;
  • 김종우 (경희대학교 동서의학연구소) ;
  • 홍남두 ((주)한국신약 방촌천연물연구소) ;
  • 김남재 (경희대학교 동서의학연구소)
  • Published : 1997.09.30
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Abstract

The ethylacetate fraction of the overground portion of Polygonum aviculare L. exhibited the anti-lipid peroxidation and the liver protective effect in intoxicated rats. Through silica gel chromatography of the ethylacetate fraction monitered by bioassay, two flavonoids, avicularin and juglanin were isolated as active components. Avicularin and juglanin remarkablely inhibited the lipid peroxidation of rat liver induced by 50% ethanol. Especially avicularin exhibited the stronger anti-lipid peroxidation effect than juglanin. Avicularin as a main principle of Polygonum aviculare L. significantly exhibited liver protective activities by decreasing s-GOT and s-LDH levels which represent for the hepatotoxicity induced by $CCl_4$ in rats. In addition, avicularin significantly decreased not only s-LDH but also s-bilirubin levels in intoxicated rat induced by ${\alpha}-naphthylisothiocyanate\;(ANIT)$. These results suggest that avicularin has the protective effects against the hepatoxicity induced by $CCl_4$ and ANIT in rats.

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