The Korean Journal of Physiology and Pharmacology
- Volume 1 Issue 4
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- Pages.393-402
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Mechanisms Underlying Relaxations Caused by Angiotensin II and Its Analogs in Isolated Rabbit Mesenteric Artery
- Hong, Ki-Whan (Department of Pharmacology, College of Medicine, Pusan National University,Center for Biofunctional Molecules, Postech) ;
- Park, Ji-Young (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Kim, Chi-Dae (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Lee, Won-Suk (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Rhim, Byung-Yong (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Yoo, Sung-Eun (Korea Research Institute of Chemical Technology)
- Published : 1997.08.21
Abstract
In the present study, we characterized the angiotensin II (AII)-induced relaxations in the phenylephrine-precontracted rabbit mesenteric arteries with endothelium. 1) AII-induced relaxation was consistently observed in the rabbit mesenteric arteries with and without endothelium, but not in the aortic segment with endothelium. 2) AII-induced endothelium-dependent relaxation was markedly inhibited by