The Korean Journal of Physiology and Pharmacology
- 제1권2호
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- Pages.201-208
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Platelet-Activating Factor Enhances Interleukin-1 Activity by Alveolar Macrophages : Inhibition by PAF Specific Receptor Antagonists
- Lee, Ji-Hee (Department of Physiology, College of Medicine, Ewha Womans University and Division of Cell Biology, Ewha Medical Research Center)
- 발행 : 1997.04.21
초록
It is becoming increasingly clear that the inflammatory reaction can be ascribed to a complex array of mediators generated and released from activated phagocytes. In this study, the effect of PAF on interleukin-1(IL-1) activity by rat alveolar macrophages(AM) was examined using thymocyte proliferation assay in the supernate of sample obtained after 24 hr culture. When AM were cultured with PAF alone, no change in IL-1 activity was observed. However, the combined addition of PAF and muramyl dipeptide(MDP) or lipopolysaccharide(LPS) to AM cultures markedly enhanced IL-1 activity by 2-3 fold compared with AM cultures with the stimulant alone in a concentration dependent fashion. The peack effect was found at