The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Inhibitory Effects of Reversible Proton Pump Inhibitors YH 1238 and YH1885 on Acid Secretion in Isolated Gastric Cells

분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과

  • Kim Hye-Young (Department of Pharmacology, Yonsei University College of Medicine) ;
  • Kim Dong-Goo (Department of Pharmacology, Yonsei University College of Medicine) ;
  • Lee Bong-Yong (Yuhan Research Center, Yuhan Corporation) ;
  • Lee Jong-Wook (Yuhan Research Center, Yuhan Corporation) ;
  • Kim Kyung-Hwan (Department of Pharmacology, Yonsei University College of Medicine)
  • 김혜영 (연세대학교 의과대학 약리학교실) ;
  • 김동구 (연세대학교 의과대학 약리학교실) ;
  • 이봉용 (유한양행 중앙연구소) ;
  • 이종욱 (유한양행 중앙연구소) ;
  • 김경환 (연세대학교 의과대학 약리학교실)
  • Published : 1997.06.01
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Abstract

Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of $[^{14}C]-aminopyrine\;and\;[^{14}C]-glucose$ oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP$(10^{-3}M)$ were used and the inhibitory effects of YH1238 and VH1885 on acid secretion were compared with known proton pump inhibitors such as omerrazole and SK&F 96067. Dibutyryl cAMP stimulated the $[^{14}C]-aminopyrine$ accumulation and $[^{14}C]-glucose$ oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on $[^{14}C]-aminopyrine$ accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of $10^{-5}M$. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.

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