The Journal of the Korean bone and joint tumor society (대한골관절종양학회지)
- Volume 2 Issue 1
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- Pages.38-46
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- 1996
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- 1226-4962(pISSN)
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- 2233-9841(eISSN)
Role of Surgery in Ewing's Sarcoma Treatment
유잉 육종의 치료에서 수술의 역할
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Jeon, Dae-Genn
(Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Lee, Jong-Seok (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Kim, Sug-Jun (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Park, Hyun-Soo (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Jang, Jin-Dae (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
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Lee, Soo-Yong
(Department of Orthopedic Surgery, Korea Cancer Center Hospital)
-
전대근
(원자력병원 정형외과) ;
- 이종석 (원자력병원 정형외과) ;
- 김석준 (원자력병원 정형외과) ;
- 박현수 (원자력병원 정형외과) ;
- 장진대 (원자력병원 정형외과) ;
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이수용
(원자력병원 정형외과)
- Published : 1996.04.30
Abstract
The traditional methodology in Ewing's sarcoma was chemotherapy and radiotherapy. Recently surgery is reemerging as an important therapeutic tool and some paper report increased survival with it. The purpose of this nonrandomized study is to evaluate our result of Ewing's sarcoma with surgery, retrospectively. We experienced 30 cases for seven years and among them 6 were extraskeletal. In location, axial was 10 cases and peripheral was 20. By Enneking's classification, state IIB was 26 cases and IIIB was 4. Eighteen patients took operation, chemotherapy and/or radiotherapy, and remaining twelve took chemotherapy and/or radiotherapy only. Type of operation was limb salvage in 16 cases and amputation 2. Average dosage of radiation was 45.1Gy. Six kinds of chemotherapeutic regimen were used, but among them main protocols were Ifosfamide-Adriamycin(17 cases) and IESS(Cytoxan, Adriamycin, Methotrexate, Vincristine:8 cases). Complications were as follows. In operation group, there were 3 local recurrence and one case of nonunion. In nonoperated group, one local recurrence and one pancytopenia resulting in death. Average follow up was 29.7 months. Kaplan-Meier's ten year actuarial survival rate for the whole 30 cases was 26.8%. Significant difference in survival exists between central and peripheral lesions(p=0.05, by log rank test). Types of chemotherapy and surgery itself showed no significance. But surgery is important in function and local control. More intensive chemotherapeutic regimen to prevent distant metastasis and combined surgery and radiotherapy may be needed in Ewing's sarcoma.