대한골관절종양학회지 (The Journal of the Korean bone and joint tumor society)
- 제2권1호
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- Pages.27-32
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- 1996
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- 1226-4962(pISSN)
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- 2233-9841(eISSN)
Stage II B형 골육종에 대한 술전 항암화학요법 및 수술적 치료 결과
Clinical Results of Neo-Adjuvant Chemotherapy and Surgery on Osteosarcoma
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강용구
(가톨릭대학교 의과대학 정형외과학교실, 근골격계 종양연구회) ;
- 김형민 (가톨릭대학교 의과대학 정형외과학교실, 근골격계 종양연구회) ;
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이승구
(가톨릭대학교 의과대학 정형외과학교실, 근골격계 종양연구회) ;
- 우영균 (가톨릭대학교 의과대학 정형외과학교실, 근골격계 종양연구회) ;
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김정만
(가톨릭대학교 의과대학 정형외과학교실, 근골격계 종양연구회) ;
- 김훈교 (가톨릭대학교 의과대학 내과학교실, 근골격계 종양연구회)
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Kang, Yong-Koo
(Department of Orthopedic Surgery, Catholic University Medical College) ;
- Kim, Hyung-Min (Department of Orthopedic Surgery, Catholic University Medical College) ;
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Rhee, Seung-Koo
(Department of Orthopedic Surgery, Catholic University Medical College) ;
- Woo, Young-Kyun (Department of Orthopedic Surgery, Catholic University Medical College) ;
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Kim, Jung-Man
(Department of Orthopedic Surgery, Catholic University Medical College) ;
- Kim, Hoon-Kyo (Department of Internal Medicine, Catholic University Medical College)
- 발행 : 1996.04.30
초록
Recent advances in imaging techniques, surgery and combination anti-cancer chemotherapy have brought high survival rates in osteosarcoma. To investigate the survival rate, local recurrence and complications in treatment, we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy, surgery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995, 42 cases of stage IIB osteosarcoma were admitted in Department of Orthopedic Surgery. Among them, 17 cases who didn't follow our treatment guidance were excluded in this study. The average age were 19 years. There were 21 males and 4 females. The involved sites were 4 humerus, 10 femur, 10 tibia and 1 talus. Eleven cases had received intraarterial cisplatin and intravenous adriamycin chemotherapy, and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate, cisplatin. Twenty-three cases were treated with limb salvage surgery, and 2 amputation. The average follow-up was 35 months(3~82). There were 14 cases of continuous disease free, 9 cases of died of disease, 1 case of alive with disease, and 1 case of no evidence of disease at final follow-up. There were three cases of local recurrence at 6,8 and 12 months after operation. The estimated Kaplan-Meier's 5 year survival rates for all, ADR-cisplatin group, T-10 protocol group, and ifosfamide regimen group were 6%, 73%, 44% and 72%, respectively.