The Korean Journal of Pain
- Volume 9 Issue 1
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- Pages.39-45
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- 1996
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Effects of Dextromethorphan on the Development of Tachyphylaxis to Sciatic Nerve Blockade Induced by 2-Chloroprocaine in the Rat
2-chloroprocaine에 의한 쥐좌골신경 차단시 발생한 급성내성에 대한 Dextromethorphan의 영향
- Park, Myong-Su (Department of Anesthesiology, Pain clinic, School of Medicine) ;
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Lee, Kang-Chang
(Department of Anesthesiology, Pain clinic, School of Medicine) ;
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Kim, Tai-Yo
(Department of Anesthesiology, Pain clinic, School of Medicine)
- Published : 1996.06.01
Abstract
Tachyphylaxis to local anesthetics has shown to be promote longer interanalgesic intervals between injections. Previous study demonstrated thermal hyperalgesia accelerates development of tachyphylaxis to sciatic nerve blockade in rats, while MK-801 prevents development of tachyphylaxis. Dextromethorphan is one of NMDA receptor antagonist similar to MK-801. A hypothesis that dextromethorphan would prevent the development of tachyphylaxis was tested in this study. A catheter was surgically implanted along the sciatic nerve a in rat. After recovery from surgery, the animal received repeated injections of 3% 2-chloroprocaine followed by motor block testing with or without hot-plate testing at