The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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Demonstration of TCM-9 Monoclonal Antibody in Follicular Neoplasm of Thyroid

갑상선의 여포상 종양의 감별에 있어서 TCM-9의 발현양상

  • Kim, Yun-Jung (Department of Pathology, Hallyrn University, College of Medicine) ;
  • Shim, Jung-Weon (Department of Pathology, Hallyrn University, College of Medicine) ;
  • Ahn, Hye-Kyung (Department of Pathology, Hallyrn University, College of Medicine) ;
  • Park, Young-Euy (Department of Pathology, Hallyrn University, College of Medicine)
  • 김윤정 (한림대학교 의과대학 병리학 교실) ;
  • 심정원 (한림대학교 의과대학 병리학 교실) ;
  • 안혜경 (한림대학교 의과대학 병리학 교실) ;
  • 박영의 (한림대학교 의과대학 병리학 교실)
  • Published : 1996.12.30
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Abstract

Monoclonal antibody(TCM-9) against human thyroid cancers have been studied by screening with human thyroid cancers, normal and benign thyroid tissue, and normal human serum protein. A monoclonal antibody(TCM-9) that is known to have strong specificity for human thyroid cancer but not for Graves' disease, adenoma or normal thyroid does not bind to native or mature human thyroglobulin(Tg). We used to TCM-9 antibody by immunohistochemical staining on 5 follicular cancer, 2 follicular adenoma, 1 follicular neoplasm with suspicious invasion, 2 papillary cancer to ascertain being of help in differentiation between follicular carcinoma and adenoma. Reactivity of TCM-9 was observed in follicular carcinoma and papillary carcinoma but not observed in follicular adenoma. Thus TCM-9 is a novel monoclonal antibody against the thyroid cancer.

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