Journal of Korean Academy of Oral and Maxillofacial Radiology (치과방사선)

Korean Academy of Oral and Maxillofacial Radiology (대한영상치의학회)
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THE EFFECTS OF DIABETES ON THE RAT PAROTID GLAND

당뇨병이 백서의 이하선에 미치는 영향에 관한 실험적 연구

  • Park Chull-Jea (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
  • Hwang Eui-Hwan (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
  • Lee Sang-Rae (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University)
  • 박철제 (경희대학교 치과대학 구강악안면방사선학 교실) ;
  • 황의환 (경희대학교 치과대학 구강악안면방사선학 교실) ;
  • 이상래 (경희대학교 치과대학 구강악안면방사선학 교실)
  • Published : 1996.08.01
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Abstract

The purpose of this study was to observe microscopic change of salivary gland tissue, which is a cause of xerostomia in diabetic condition; for this target, the author injected streptozotocin 0.1ml/100 gm b.w. on the rat, Sprague Dawley, to induce diabetes, and then observed microscopic changes in parotid gland tissue using light microscopy and electron microscopy. The results were as follows : 1. Parotid gland tissue of the diabetic rat was atrophied or degenerated in lapse of experimental time, but began to repair from 14 days after diabetic induction. 2. In the basal lamina of the vessel of parotid gland tissue in the diabetic rat, lamina lucida was discontinued and lamina densa was increased in thickness, but the number of capillary was gradually increased and dilated. 3. In acinic and intercalated ductal cells of parotid gland in the diabetic rat, changes of mitochondria, RER, secretory granule, free ribosome were prominent. In conclusion, the present study demonstrated that degenerative changes of the parotid gland tissue were due to not completely thickening of the basal lamina of vessels, but many other causal factors, because thickness of the basal lamina of vessels was not related with degenerative changes.

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