YAKHAK HOEJI (약학회지)
- Volume 40 Issue 5
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- Pages.550-557
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
The Antifibrotic Effects of D-penicillamine in Liver Fibrosis Animal
간섬유화 동물에서 D-페니실라민의 항섬유화 효과 검색
- Kim, Gi-Yeong (Pathology, College of Medicine, Wonkwang University) ;
- Yun, Gi-Jung (Pathology, College of Medicine, Wonkwang University) ;
- Mun, Hyeong-Bae (Pathology, College of Medicine, Wonkwang University)
- Published : 1996.10.01
Abstract
One of therapeutics in liver disease (morbus wilson) is D-penicillamin (D-pen: D-3-mercapto-valin). Especially the cross-linking of collagen molecules could be inhibited by D-pe n in extracellular space. In this study we investigated the antifibrotic effects of D-pen in rats that were induced the liver fibrosis by bile duct ligation and scission (BDL/S). Rats were treated for 4 weeks with D-pen after BDL/S operation or sham operation. The balance between fibrogenesis-marker (PNIIIP) and the fibrolysis-maker (PNIVP) were observed in sera by RIA (radioimmunoassay), and the parameter of collagen deposition in liver tissue (hydroxyproline: HYP) was measured by colorimetry. The weight of liver in BDL/S operated group was increased significantly in compared with sham operation group (15.2g
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