약학회지 (YAKHAK HOEJI)
- 제40권3호
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- Pages.357-368
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
플로오로퀴놀론계 항생제인 DWP20373의 in vitro 항균작용
Evaluation of in vitro antibacterial Activity of DWP20373, a Novel Fluoroquinolone
- 김지연 ((주)대웅제약 중앙연구소) ;
- 최문정 ((주)대웅제약 중앙연구소) ;
- 한승희 ((주)대웅제약 중앙연구소) ;
- 김병오 ((주)대웅제약 중앙연구소) ;
- 심점순 ((주)대웅제약 중앙연구소) ;
- 정연의 ((주)대웅제약 중앙연구소) ;
- 이재욱 ((주)대웅제약 중앙연구소) ;
- 유영호 ((주)대웅제약 중앙연구소) ;
- 박명환 ((주)대웅제약 중앙연구소)
- Kim, Ji-Yeon (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Choi, Moon-Jung (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Han, Seung-Hee (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Kim, Byung-O (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Shim, Jeom-Soon (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Jung, Yeon-Eui (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Lee, Jae-Wok (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Yu, Young-Hyo (R & D Center, Daewoong Pharmaceutical Co., Ltd.) ;
- Park, Myung-Hwan (R & D Center, Daewoong Pharmaceutical Co., Ltd.)
- 발행 : 1996.06.01
초록
The in vitro antibacterial activity of a novel fluoroquinolone, DWP20373(1-Cyclopropyl-6-fluoro-8-methoxy-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4 oxoquino line-3carboxylic acid) was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20373 was more active than SPFX and OFLX but was less potent than CPFX against gram-negative bacteria. DWP20373 showed an excellent activity against L-MRSA and H-MRSA (