YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Evaluation of in vitro antibacterial Activity of DWP20373, a Novel Fluoroquinolone

플로오로퀴놀론계 항생제인 DWP20373의 in vitro 항균작용

  • 김지연 ((주)대웅제약 중앙연구소) ;
  • 최문정 ((주)대웅제약 중앙연구소) ;
  • 한승희 ((주)대웅제약 중앙연구소) ;
  • 김병오 ((주)대웅제약 중앙연구소) ;
  • 심점순 ((주)대웅제약 중앙연구소) ;
  • 정연의 ((주)대웅제약 중앙연구소) ;
  • 이재욱 ((주)대웅제약 중앙연구소) ;
  • 유영호 ((주)대웅제약 중앙연구소) ;
  • 박명환 ((주)대웅제약 중앙연구소)
  • Published : 1996.06.01
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Abstract

The in vitro antibacterial activity of a novel fluoroquinolone, DWP20373(1-Cyclopropyl-6-fluoro-8-methoxy-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4 oxoquino line-3carboxylic acid) was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20373 was more active than SPFX and OFLX but was less potent than CPFX against gram-negative bacteria. DWP20373 showed an excellent activity against L-MRSA and H-MRSA ($MlC_{90}=0.781{\sim}1.563{\mu}g/ml$).The activity of DWP20373 decreased moderately in the presence of 5mM $Mg^{2+}$. However, pH and serum had no effect on the activity of DWP20373. DWP20373 possessed a rapid bactericidal activity against gram-positive and gram-negative strains.

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