YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of a New Fluoroquinolone LB20304a on Microflora of Caecum in Mice

새로운 플루오로퀴놀론계 항생제 LB20304a가 생쥐의 맹장내 세균총에 미치는 영향

  • Ahn, Mi-Jeong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
  • Paek, Kyoung-Sook (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
  • Kim, Mu-Yong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
  • Kim, In-Chull (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
  • Kwak, Jin-Hwan (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.)
  • 안미정 (LG화학 기술연구원, 바이오텍연구소) ;
  • 백경숙 (LG화학 기술연구원, 바이오텍연구소) ;
  • 김무용 (LG화학 기술연구원, 바이오텍연구소) ;
  • 김인철 (LG화학 기술연구원, 바이오텍연구소) ;
  • 곽진환 (LG화학 기술연구원, 바이오텍연구소)
  • Published : 1996.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The influence of LB20304a, a new fluoroquinolone antibiotic agent, on microflora of caecum in mice was compared with those of ciprofloxacin and piperacillin after administration of drugs for 5 days. Selective medium (CCFMA) was used for the isolation of Clostridium difficile from the specimens of mouse caecum. The emergence of C. difficile in mouse caecum induced by LB20304a was lower than that by ciprofloxacin or piperacillin at day 1 and day 7 after completing administration of drugs.

Keywords