YAKHAK HOEJI (약학회지)
- Volume 40 Issue 5
- /
- Pages.487-490
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Phenolbetaine Derivatives and Their Anti-cancer Activity: Chemical Transformation of C-ring of Protoberberine
페놀베타인 유도체합성 및 항암 활성검토: 프로토베르베린에서 C-환의 화학적 변환
- U, Seong-Ju (College of Pharmacy, Kyung Hee University) ;
- Park, Ye-Jin (College of Pharmacy, Kyung Hee University) ;
- Hwang, Sun-Ho (College of Pharmacy, Kyung Hee University) ;
- Hong, Yu-Hwa (College of Pharmacy, Kyung Hee University) ;
- Lee, Ma-Se (College of Pharmacy, Kyung Hee University) ;
-
Kim, Dong-Hyeon
(College of Pharmacy, Kyung Hee University)
;
- Kim, In-Jong (College of Pharmacy, Kyung Hee University) ;
- Kim, Sin-Gyu (College of Pharmacy, Kyung Hee University)
- 우성주 (경희대학교 약학대학) ;
- 박예진 (경희대학교 약학대학) ;
- 황순호 (경희대학교 약학대학) ;
- 홍유화 (경희대학교 약학대학) ;
- 이마세 (경희대학교 약학대학) ;
-
김동현
(경희대학교 약학대학)
;
- 김인종 (경희대학교 약학대학) ;
- 김신규 (경희대학교 약학대학)
- Published : 1996.10.01
Abstract
The 13-hydroxyberbine(1), derived from berberinephenolbetaine, has been derivatized to furnish a variety of compounds such as 13-oxoberbine(2), 13-thioberbine(3), 13-chloroberbi ne(4), 13-(2-methylaziridine)berbine(5) and 13-carbolactoneberbine(6). Antitumor activity of these compounds was tested.
Keywords