YAKHAK HOEJI (약학회지)
- Volume 40 Issue 2
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- Pages.202-211
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Immunobiological Studies on Route of Administration of Amygdalin
아미그달린의 투여경로에 따른 면역생물학적 연구
- Kim, Joung-Hoon (Center for Food and Drug Safety, Wonkwang University) ;
- Kang, Tae-Wook (Center for Food and Drug Safety, Wonkwang University) ;
- Park, Chan-Bong (Center for Food and Drug Safety, Wonkwang University) ;
- Cha, Kwang-Jae (Center for Food and Drug Safety, Wonkwang University) ;
- Ahn, Young-Keun (Center for Food and Drug Safety, Wonkwang University)
- 김정훈 (원광대학교 식품약품안전성연구소) ;
- 강태욱 (원광대학교 식품약품안전성연구소) ;
- 박찬봉 (원광대학교 식품약품안전성연구소) ;
- 차광재 (원광대학교 식품약품안전성연구소) ;
- 안영근 (원광대학교 식품약품안전성연구소)
- Published : 1996.04.01
Abstract
Experiments were performed on male Sprague-Dawley rats to investigate the immunobiological effects on route of administration of amygdalin(AM). Rats were administered orally at 12.5, 25, or 50mg/kg/day of AM or injected wtih 25,50, or 100mg/kg/day of AM intravenously for 2 weeks. Rats were immunized and challenged with sheep red blood cells(SRBC). The results of this study were summarized as follows;(1) In oral administration of AM, body weight gains were significantly increased by 50mg/kg AM as compared with controls, the relative weights of liver and thymus also were significantly increased by 12.5 and 25mg/kg AM. However, 2-mercaptoethanol-resistant hemagglutination titier (2-MER HA), Plaque forming cells (PFC) and rosette forming cells (RFC) were non-dose dependently decreased. Phagocytic activity and delayed-type hypersensitivity (DTH) reaction also were significantly decreased by 50mg/kg AM. (2) In intravenous injection of AM, body weight gains, hemagglutination titer (HA), 2MER-HA, DTH reaction, PFC, RFC and circulating leukocytes were not influenced by AM. However, the relative weights of liver, spleen and thymus were significantly enhanced 100mg/kg AM. These results indicated that oral administration of AM non-dose dependently suppresses humoral and cell-mediated immunity in SD rats, and that intravenous injection of AM is unaffected humoral and cell-mediated immunity, however, the high dose of it significantly enhances phagocytic activity.