YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Differentiation Effect of Marine Natural Compounds on F9 Teratocarcinoma Stem Cells

F9 기형암종 세포에 대한 해양천연물질의 분화 유도 작용

  • Kim, Li-La (Department of Molecular Biology, Pusan National University) ;
  • Baek, Jin-Hyen (Department of Molecular Biology, Pusan National University) ;
  • Cho, Yong-Jin (Department of Chemistry, National Fisheries University of Pusan) ;
  • Son, Byung-Wha (Department of Chemistry, National Fisheries University of Pusan) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Kim, Kyu-Won (Department of Molecular Biology, Pusan National University)
  • 김리라 (부산대학교 분자생물학과) ;
  • 백진현 (부산대학교 분자생물학과) ;
  • 조용진 (부산수산대학교 화학과) ;
  • 손병화 (부산수산대학교 화학과) ;
  • 최홍대 (동의대학교 화학과) ;
  • 김규원 (부산대학교 분자생물학과)
  • Published : 1996.12.01
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Abstract

It has been known that many kinds of cancer are caused by continued proliferation or abnormal differentiation. Thus, recent approaches to anticancer therapy have been focused on developing drugs that induce differentiation of cancer cells to normal cells. A typical differentiation agent, all trans-retinoic acid, is unsuitable for anticancer drug because all trans-retinoic acid produces unfavorable side effects and cytotoxicity in normal cells. Therefore, we have screened some new differentiation-inducing compounds obtained from marine organisms using F9 teratocarcinoma stem cells as a model system. We observed that fatty acid. glycolipid, saponin, sphingosine and sterol compounds of marine organisms had differentiation-inducing activity in F9 cells, were determined by morphological changes and Northern blot analysis. The expression of differentiation marker genes, such as laminin B1, type IV collagen and retinoic acid receptor beta were induced by treatment with those compounds.

Keywords

References

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