YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Properties and Application as the Indicator of N-4-Salicyloamido-2-Amino-6-Piperidinopyrimidine 3-Oxide Fe(III) Complex

N-4-살리실로아미도-2-아미노-6-피페리디노피리미딘 3-옥사이드${\cdot}$철(III) 착체의 물성 및 지시약적 응용성

  • Published : 1996.12.01
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Abstract

The combinations of N-4-salicyloamido-2-amino-6-piperidinopyrimidine 3-oxide (Salmi) and two transitional metals were colored. Among metals, Fe(III) made a distinct colored comp lex with Salmi. The mole ratio of Salmi and Fe(III) in the complex was 1:1. This Salmi-Fe(III) complex was recrystallized in Hexane/Acetone(=10/1, v/v) and investigated its physicochemical properties. The color of this complex was changed by pH.; deep violet pink in acids, orange in neutral, and yellow in bases. The range of color change was approximately 0.7 pH unit. Acid-base titration of various acidic or basic drugs using Salmi-Fe(III) complex as an indicator showed good accuracy and reproducibility.

Keywords

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