약학회지 (YAKHAK HOEJI)
- 제40권2호
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- Pages.155-162
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
경피용 프로드럭인 에칠 글리콜레이트의 국소자극 및 피부투과성
Skin Penetration and Local Irritation of Ethyl Glycolate, a Potential Transdermal Prodrug
- Yang, Sung-Woon (College of Pharmacy, Chung-Ang University) ;
- Ha, Yong-Ho (Lamy Cosmetic Co., Ltd.) ;
- Kim, Johng-Kap (College of Pharmacy, Chung-Ang University) ;
- Choi, Young-Wook (College of Pharmacy, Chung-Ang University)
- 발행 : 1996.04.01
초록
Hyperkeratinization is a dermatologic disorder, which is due to the increase of corneocyte cohesion force. Glycolic acid, an alpha hydroxy acid(AHA), has been used to breakdown the hyperkeratinization processes. However, it has a problem of skin irritation when applied topically, due to the strong acidity especially in high concentration. A molecular optimization of glycolic acid has been tried to reduce the skin irritation by the way of prodrug formation. Ethyl glycolate was synthesized by the esterification of glycolic acid with ethanol in acidic conditions in the presence of sulfuric acid, and examined under the spectroscopic trials, such as UV, IR,
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