당첨가가 한탄바이러스백신의 안정성에 미치는 영향

Effect of Addition of Sugar on the Stability of Hantaan Virus Vaccine

  • 성인화 (고려대학교 의과대학 미생물학교실, 고려대학교부설 바이러스병연구소)
  • Seong, In-Wha (Department of Microbiology, Medical College, the Institute for Viral Diseases, Korea University)
  • 발행 : 1996.12.30

초록

Hantaan virus vaccine was developed in 1988 and proved effective. This vaccine is a kind of inactivated vaccine, stable for two years when stored at $2-8^{\circ}C$. Almost virus vaccines including Hantaan virus vaccine are produced and kept in fluid state, and the immumogenicity can be easily destroyed at room temperature or at higher temperature. Therefore the vaccines should be kept in the refrigerator to maintain the immunogenicity. In this study, glucose and/or lactose was added as a stabilizer into Hantaan virus vaccine to increase the stability and dried in vaccum with ethanol treatment. 5% glucose and or lactose in Hantaan virus vaccine most effectively increased the stability of vaccine and maintained the immunogenicity at least for three months at room temperature. But drying with ethanol treatment did not help increasing the stability. These results suggest that glucose and lactose could be good stabilizer of virus vaccines.

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