대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제26권2호
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- Pages.227-234
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- 1996
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- 1225-2344(pISSN)
전립선 암조직에서의 사람파필로마바이러스의 감염과 p53단백질의 발현에 대한 연구
Human Papillomavirus Infections and p53 Expression in Prostatic Carcinoma
- 권두한 (생명공학연구소 바이러스종양 R.U., KIST) ;
- 진승원 (생명공학연구소 바이러스종양 R.U., KIST) ;
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강병태
(생명공학연구소 바이러스종양 R.U., KIST) ;
- 윤희식 (생명공학연구소 바이러스종양 R.U., KIST) ;
- 유왕돈 (제일제당(주) 종합연구소) ;
- 김현수 (제일제당(주) 종합연구소) ;
- 이상숙 (계명의대 임상병리학교실) ;
- 이호자 (생명공학연구소 바이러스종양 R.U., KIST) ;
- 박순희 (경희대학교 생물학과)
- Kwon, Dur-Han (Virus/Oncology R.U.., Kor. Res. Ins. of Biosci. & Biotech.) ;
- Jin, Seung-Won (Virus/Oncology R.U.., Kor. Res. Ins. of Biosci. & Biotech.) ;
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Kang, Byung-Tae
(Virus/Oncology R.U.., Kor. Res. Ins. of Biosci. & Biotech.) ;
- Yoon, Hee-Sik (Virus/Oncology R.U.., Kor. Res. Ins. of Biosci. & Biotech.) ;
- Yoo, Wang-Don (R&D Ctr. of Cheil Food & Chemicals, Co.) ;
- Kim, Hyeun-Soo (R&D Ctr. of Cheil Food & Chemicals, Co.) ;
- Lee, Sang-Sook (Dept. of Ant. & Pathoi. Keimyoung Med. School) ;
- Lee, Ho-Sa (Virus/Oncology R.U.., Kor. Res. Ins. of Biosci. & Biotech.) ;
- Park, Sue-Nie (Dept. of Biol. KyeungHee Univ.)
- 발행 : 1996.12.30
초록
Prostatic carcinoma is the leading second cause of cancer in men. Previous epidermiological studies implicated human papillomavirus as an infectious agent. Since there are only limited studies on the association of HPV to prosate cancer, we examined the prevalence of HPV infections in korean prostate cancer patients. We observed that out of 26 cases, 4 cases and 5 cases were infected by HPV 16(27%) and HPV 18 (31%), respectively and 3 cases by both (46%) and at least 18 were positive for HPV (69%). For these samples, immunohistochemical detection of the p53 and proliferative cell nuclear antigen (PCNA) were also studied, using monoclonal antibodies. Sixteen of 26 (61%) showed immunostaining for p53 protein. While 8 samples with no HPV infection (100%) showed all positive for p53 protein staining, less than half of the 18 patients with any HPV infection (44%) showed p53 protein staining. These findings indicate that altered expression of p53 protein occurs in the more than half of prostate cancers, however, p53 expression is less frequent in HPV infected tissues. This implies that there might be an inverse correlation in general between HPV infection and p53 amplification. However, while 50% (4 of 8) of HPV negative prostate cancer was positive for PCNA staining, 13 out of 18 HPV infected patients (72%) were positive. Therefore HPV infection is more strongly associated with increase proliferation. In addition HPV infected cancer patients are generally in more advanced status implying that HPV infection plays a role in the development of highly malignant prostatic carcinomas, eventhough the statistical significance of this interpretation might be waited for the analysis of more cases.