The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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[I-123]IPT SPECT Dopamine Reuptake Site Imaging: Differences in Normal Controls and Parkinson's Patients by Semiquantitative Analysis Methods

[I-123]IPT SPECT를 이용한 도파민 재섭취부위의 영상화: 반정성적 분석방법을 이용한 정상인과 파킨슨병 환자의 차이

  • Kim, Hee-Joung (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan) ;
  • Im, Joo-Hyuck (Departments of Neurology, Asan Medical Center, University of Ulsan) ;
  • Yang, Seoung-Oh (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan) ;
  • Ryu, Jin-Sook (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan) ;
  • Choi, Yun-Young (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan) ;
  • Lee, Myung-Chong (Departments of Neurology, Asan Medical Center, University of Ulsan) ;
  • Lee, Hee-Kyung (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan)
  • 김희중 (울산대학교 서울중앙병원 핵의학과) ;
  • 임주혁 (울산대학교 서울중앙병원 신경과) ;
  • 양승오 (울산대학교 서울중앙병원 핵의학과) ;
  • 류진숙 (울산대학교 서울중앙병원 핵의학과) ;
  • 최윤영 (울산대학교 서울중앙병원 핵의학과) ;
  • 이명종 (울산대학교 서울중앙병원 신경과) ;
  • 이희경 (울산대학교 서울중앙병원 핵의학과)
  • Published : 1996.03.25
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Abstract

Dopamine transporter concentrations have been known to decrease in Parkinson's disease (PD) or increase in Tourette's disorder. The purpose of this study was to evaluate the effectiveness of [I-123]N-(3-iodopropene-2-yl)-$2{\beta}$-carbomethoxy-$3{\beta}$-(4-chlorophenyl) tropane (IPT) as an imaging agent for measuring changes in transporter concentrations with PD. IPT labelled with 6.69+/-0.64 mCi(247.53+/-23.68 MBq) of I-123 was intravenously injected into ten patients(age: 55+/-11) with PD, and six normal controls(NC)(age: 46+/-14) as a bolus. Dynamic SPECT scans of the brain were then performed for 5 minutes each over 120 minutes on a triple headed camera. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBC), and occipital cortex(OCC). The statistical parameters included the time to peak activity, the contrast ratio of LBG and RBG to OCC at several time points, and the accumulated specific binding counts/mCi/pixel(ASBC) from 0 to 115 minutes. The uptake of IPT in the brains of PD and NC peaked within 10 minutes of injection in all subjects. The maximum target to background ratio in the basal ganglia of PD and NC occurred at 85+/-20 min and 110+/-6 min of injection, respectively. The BG/OCC ratios at 115 minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73, respectively. The ASBC at 115 minutes for PD and NC were 152.91+/-50.09 and 289.51+/-49.00, respectively. The ratio of BG/OCC for the NC was significantly higher than the ratio for PD. SPECT data matched with clinical diagnosis for PDs. The ratio between BG and OCC and the ASBC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. The findings suggest that IPT may be a very useful tracer for early diagnosis of PD and study of dopamine reuptake site.

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