Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis of New 5-Benzyl-4-cyanomethyl-2-methylpyrimidine Derivatives

새로운 5-Benzyl-4-cyanomethyl-2-methylpyrimidine 유도체들의 합성

  • 김정환 (영남대학교 이과대학 화학과) ;
  • 한문수 (영남대학교 이과대학 화학과)
  • Published : 19960400
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Abstract

The synthesis of new 5-benzyl-4-cyanomethyl-2-methylpyrimidine derivatives (5) containing chloro, methoxy, ethoxy, phenoxy and anilino groups at 6-position on the pyrimidine ring were prepared from 5-benzyl-4-chloro-2-methylpyrimidine derivatives (3) and tert-butylcyanoacetate. The derivatives of 5-benzyl-4-chloro-2-methylpyrimidine (3) containing chloro, methoxy, ethoxy, isopropoxy, phenoxy and anilino groups at 6-position on the pyrimidine ring were prepared from 5-benzyl-4,6-dichloro-2-methylpyrimidine (2).

5-Benzyl-4-cyanomeygyl-2-methylpyrimidine의 6번 위치에 chloro, methoxy, ethoxy, phienoxy, 및 anilino기가 도입된 새로운 유도체(5)들의 합성은5-Benzyl-4-cyanomeygyl-2-methylpyrimidine 유도체(3)들과 tert-butylcyanoacetate로부터 합성되었으며, 5-Benzyl-4-cyanomeygyl-2-methylpyrimidine의 6번 위치에 chloro, methoxy, ethoxy, isopropoxy, 및 anilino기가 도입된 유도체(3)들은 5-Benzyl-4-cyanomeygyl-2-methylpyrimidine(2)로부터 합성되었다.

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References

  1. Brit. pat. 1,122,459 Brand, E.;Weiz, L.;Moehring, M.
  2. Eur. pat. 130,735 Bagli, J. F.
  3. Organic Chemistry Hart, H.
  4. J. Org. Chem. v.30 Borror, A. L.;Haeberer, A. F.
  5. J. Korean Chem. v.34 Kim, J. H.;Seo, J. H.
  6. Org. Synth. Coll. v.Ⅲ Marvel, C. S.
  7. J. Am. Chem. Soc. v.73 Langerman, M. J.;Banks, C. K.
  8. J. Am. Chem. Soc. v.63 Sprague, J. M.;Kissinger, L. W.;Lincoln, R. M.
  9. J. Chem. Soc. Hendry, J. A.;Homer, R. F.
  10. J. Chem. Soc. Hull, R.
  11. J. Am. Chem. Soc. v.69 Braker, W.;Pribyl, E. J.;Sheehan, J. T.;Spitzmiller, E. R.;Lott, W. A.
  12. J. Am. Chem. Soc. v.79 Henze, H. R.;Winthrop, S. O.
  13. J. Chem. Soc. Caton, M. P. L.;Grant, M. S.;Pain, D. L.;Slack, R.
  14. J. Chem. Soc. Rose, F. L.;Tuey, G. A. P.
  15. J. Med. Chem. v.11 Ghosh, D.;Mukherjee, M.