Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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$\beta$ -Lactam Derivatives as Inhibitors for Carboxypeptidase A. Enzyme Inhibitor Design, Part 17

  • Published : 19960100
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Abstract

2-(Azetidin-2-one-1-yl)-3-phenylpropionic acid and 2-(azetidin-2-thione-1-yl)-3-phenylpropionic acid were designed as potential active site directed inactivators for carboxypeptidase A, but shown to be they are competitive reversible inhibitors for the enzyme. The observation was somewhat surprising, but is not unexpected considering the recent report of Page who questioned the validity of the generally believed notion that $\beta-lactam$ ring is highly unstable.

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