Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Skin Irritation Study of the Syndella Gel, Topical Drug Containing Deproteinised. Dialysate of Calf′s Blood and Micronomicin Sulfate Rabbits

토끼에서 신델라 겔(송아지의 제단백혈액추출물: 황산 미크로노마이신=20:1 혼합물)의 피부자극성시험

  • 남석우 (성균관대학교 약학대학) ;
  • 이영진 (성균관대학교 약학대학) ;
  • 고영권 (성균관대학교 약학대학) ;
  • 장만식 (영진약품공업(주) 중앙연구소) ;
  • 최완수 (영진약품공업(주) 중앙연구소) ;
  • 김규봉 (영진약품공업(주) 중앙연구소) ;
  • 우태욱 (영진약품공업(주) 중앙연구소) ;
  • 한정환 (성균관대학교 약학대학) ;
  • 홍성렬 (성균관대학교 유전공학과)
  • Published : 1996.12.01
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Abstract

This study was conducted to investigate the skin irritation toxicity of Syndella gel, a combination topical drug containing a deproteinised dialysate of calf's blood and micronomicin sulfate in the ratio of 20 to 1, in New Zealand White rabbits. In the primary skn irritation test with male New Zealand White rabbits, there was no treatment-related effect on clinical sign, nd body weight was not significantly changed. The Primary Irritation index (PII) was 0.33, indicating that Syndella gel was a mildly irritating formulation.

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