Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Micromonospora sp. SA-246 균주가 생산하는 Isochromanequinone계 항생물질

  • 여운형 (충남대학교 농생물학과) ;
  • 윤봉식 (충남대학교 농생물학과) ;
  • 황경숙 (목원대학교 미생물학과) ;
  • 이정옥 (한국화학연구소 의약활성실) ;
  • 유승헌 (충남대학교 농생물학과)
  • Published : 1996.06.01
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Abstract

In the course of screening for new bioactive compounds from oligotrophs in soil, a microorganism, designated as SA-246 and now identified as Micromonospora sp., has been shown to produce a strong antibacterial compound. The active compound was purified from broth filtrate by ethylacetate extraction, silica gel column chromatography, preparative TLC and HPLC, and was identified as crisamicin A based on mass and NMR spectral data. The compound SA- 246 exhibited not only strong antibacterial activity against Gram-positive bacteria but also cytotoxicity against cancer cell lines such as A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT15 (colon).

Keywords

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