Toxicological Research

  • 제12권2호
  • /
  • Pages.181-194
  • /
  • 1996
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Sanjoinine-A의 중추신경계작용 및 일반약리작용

General Pharmacology of Sanjoinine-A

  • 박찬웅 (서울대학교 의과대학 약리학교실) ;
  • 김용식 (서울대학교 의과대학 약리학교실) ;
  • 한병훈 (서울대학교 천연물과학연구소) ;
  • 박종완 (서울대학교 의과대학 약리학교실) ;
  • 장인진 (서울대학교 의과대학 약리학교실) ;
  • 최정윤 (서울대학교 의과대학 약리학교실) ;
  • 정동복 (서울대학교 의과대학 약리학교실) ;
  • 이윤송 (서울대학교 의과대학 약리학교실) ;
  • 김명석 (서울대학교 의과대학 약리학교실)
  • 발행 : 1996.12.01
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초록

The effects of Sanjoinine-A, an alkaloid isolated from Zizyphus spinosus semens, on central nervous system and general pharmacology were studied. In summary, Sanjoinine-A depress the spontaneous locomotor activity without motor incoordination and it has slight analgesic effect. Those effects are qualitatively similar to that of diazepam but its potency is much lower than diazepam(20 times). Sanjoinine-A does not depress the electric or pentylenetetrazole induced convulsion. Those effects are dissimilar with that of diazepam. Sanjoinine-A slightly depress the spontaneous or acethylchollne induced motility of smooth muscles but degree of depressant effect was variable to tissues. Sanjoinine-A does not show any effects on digestive system, blood, kidney fuction and neural ganglion.

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참고문헌

  1. 약학회지 v.15 산조인의 진정 및 향정신작용에 관한 연구 김응찬
  2. 대한약리학잡지 v.18 산조인의 중추신경 및 심혈관계에 대한 약리작용 안영수;김경환;조태순;김원준;홍사석
  3. 본초학 유시명;한대석
  4. 대한약리학잡지 v.12 no.2 산조인의 심장에 대한 약리작용 조태순;노재엽;홍사석
  5. J. Biol. Chem. v.128 A new coupling component for sulfanilamide determination Bratton,A.C.;Marshal,E.K.Jr.
  6. Immunology v.14 Furtjer imptovement in the plaque technique for detecting single antibody forming cells Cunningham,A.J.;Szenberg,A.
  7. Korean J. Pharmacog. v.16 Studies on the sedative alkaloids from Zizyphus spinosus semens Han,B.H.;Park,M.H.;Park,J.H.
  8. Pure and Appl. Chem. v.61 Chemical and Pharmacological studies on sedative cyclopeptide alkaloids in some Rhamnaceae plants Han,B.H.;Park,M.H.;Park,J.H.
  9. J. Pharm. Soc. Jap. v.60 The constituents of Zizyphus Vulgaris Lamark var. spinosus Bunge(Ⅱ) Kawaguchi,R.;Kim,K.W.
  10. Yakugaku Zasshi v.95 Acute tovicity and sedative action of Zizyphus seeds Shibata,M.;fuknshina,M.
  11. Japanese J. Pharmacol. v.23 Pharmacological studies of Zizyphus seeds Watanabe,I.;Saito,H.;Takagi,K.
  12. J. Lab. Clin. Med. v.43 Determination of inulin in plasma and urine by use of anthrone White,R.P.;Samson,F.E.Jr.