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The Pharmaceutical Society of Korea (대한약학회)
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Metabolism of glycyrrhizin and baicalin by human intestinal bacteria

  • Published : 1996.08.01
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Abstract

By human intestinal bacteria, glycyrrhizin (18${\beta}$-glycyrrhetic acid ${beta}$-D-glucuronyl.${\alpha}$-D-glucuronic acid, GL) and baicalin (baicalein ${\beta}$-D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, .${\alpha}$-glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18.${\beta}$-glycyrrhetinic acid ..${\alpha}$-D-glucuronic acid to 18${\beta}$-glycyrrhetic acid but did not baicalin. However, E. coli ${\beta}$-glucironidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL.${\beta}$-Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.

Keywords

References

  1. Microbiol. Immunol. v.26 Interferon induction by glycyrrhizin and glycyrretinic acid in mice Abe,N.;Ebina,T.;Ishida,N.
  2. Chem. Pharm. Bull. v.35 Glycyrrhizin β-D-glucuronidase of Eubacterium sp. from human intestinal flora Akao,T.;Akao,T.;Kobashi,K.
  3. Biochem. Pharmacol. v.41 Hydrolysis of glycyrrhizin to 11β-glycyrrhetyl monoglucuronide by lysosomal β-D-glucuronidase of animal livers Akao,T.;Akao,T.;Hattori,M.;Kanaoka,M.;Yamamoto,K.;Namba,T.;Kobashi.K.
  4. The J. Sino-Japan. Med. v.8 Pharmacological action of Scutellaria baicalensis Khoda,A.
  5. Planta Medica v.48 Metabolsim of glycyrrhizin by human intestinal bacteria Hattori,M.;Sakamoto,T.;Kobashi,K.;Namba,T.
  6. Biol. Pharm. Bull. v.18 Purification and characterization of β-glucuronidase from E. coli HGU-3, a human intestinal bacterium Kim.D.H.;Jin,Y.H.;Jung,E.A.;Kobashi,K.
  7. Endocriol. Jpn v.4 Study on the corticoid-like action of glycyrrhizin and mechanism of its action Kumagai,A.;Yano,M.;Otomo,M.;Takeuchi,K.
  8. Jap. Pharmacol. Ther. v.8 Enzymatic immunoassay of glycyrrhetic acid and glycyrrhizin II. Measurement of glycyrrhetic acidand glycyrrhizin in serum Nakano,N.;Kato,H.;Suzuki,H.;Nakano,N.;Yano,S.;Kanaoka,M.
  9. Nature v.281 Glycyrrhizic acid inhibits virus growth and inactivates virus particles Pompeo.R.;Flore,O.;Marccialis,M.A.;Pani,A.;Loddo,B.
  10. Chem. Pharm. Bull. v.27 Rapid estimation of glycyrrhizin and glycyrrhetic acid in plasma by high-speed liquid chromatography Sakiya,Y.;Akada,Y.;Kawano,S.;Miyauchi,Y.
  11. Biochem. Pharmacol. v.14 Biochemical study of anti-inflammatory and antiarthritic properties of glycyrretic acid Tangri,K.K.;Seth,P.K.;Parmar,S.S.;Bhargava,K.P.