Archives of Pharmacal Research
- Volume 19 Issue 5
- /
- Pages.411-415
- /
- 1996
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis and Biological Activity of C-3 Pyridinylethene-substituted Cephalosporins
- Sung, Bo-Ko (Division of Applied Science Korea Institute of Science and Technology) ;
-
Lee, Yong-Sup
(Division of Applied Science, Korea Institute of Science and Technology)
;
- Lee, Jae-Yeol (Division of Applied Science, Korea Institute of Science and Technology) ;
-
Ham, Won-Hoon
(College of Pharmacy, Sungkyunkwan University)
;
- Park, Hokoon (Division of Applied Science, Korea Institute of Science and Technology)
- Published : 1996.10.01
Abstract
A series of aminothiazolylcephalosporin derivatives (1a-1c) having pyridinylethenyl group at C-3 position was prepared starting from phosphonium salt 3 and 2-, 3- or 4-pyridinecarboxal-dehyde and the antibacterial activity of these compounds was investigated. Among them, 4-pyridinylethenyl derivative was more active than 2- and 3-pyridinylethenyl derivativees against Staphylococcus aureus and Escherichia coli.
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