Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Action of Dammarane-Type Triterpenoidal Glycosides and Their Aglycones on Lipid Membranes

지질막에 대한 Dammarane-Type Triterpenoidal Glycosides와 그 Aglycones의 작용

  • Kim, Yu.A. (Institute of Cell Siuphysics, Russian Academy of Sciences) ;
  • Park, Kyeong-Mee (Korea Ginseng and Tobacco Research Institute) ;
  • Hyun, Hack-Chul (Korea Ginseng and Tobacco Research Institute) ;
  • Song, Yong-Bum (Korea Ginseng and Tobacco Research Institute) ;
  • Shin, Han-Jae (Korea Ginseng and Tobacco Research Institute) ;
  • Park, Hwa-Jin (Department of Medical Laboratory Science College of Healthe Science, Inju University)
  • Published : 1996.12.01
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Abstract

We investigated the effects of ginseng glycosides and their aglycones on processes of single ion channel formation and channel properties. The glycosides, Rg, and Rb, , and their aglycones, 20-(S)-protopanaxatriol (PT) and 20-(S)-protopanaxadiol (PD) increased the membrane permeability for ions. PT, PD, Rg1, and Rb1; at concentrations of 0.5, 3.0, 10.0 and 30.0 $\mu\textrm{g}$/ml respectively; Induced single ion channel fluctuations with the life times in the range of 0.1~1005 in open states and conductances from 5 to 30 pS in 1 M KCI. At high concentrations of these substances, rapid fluctuations of transmembrane ion current with amplitude from hundred pS to dozen nS were observed. Against other substances, ginsenoside Rbl began to increase the membrane conductance at concentration of about 60 $\mu\textrm{g}$/ml without fluctuation of single ion channel. Membranes treated with PT, PD, Rg1 and Rb1 are more permeable to K+, than to Cl while zero current membrane potentials with 10 gradients of KCI were 12, 16, 8, 25 mV respectively. Key words : Membrane conductance, single ion channel, ginsenosides.

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