Journal of Ginseng Research
- 제20권1호
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- Pages.23-29
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- 1996
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
DPPC의 상전이에 미치는 Dammarane Series의 Triterpenoidal Glycoside와 그 Aglycone의 영향
Effect of Triterpenoidal Glycosides of Dammarane Series and Their Aglycones on Phase Transitions of Dipalmitoylphosphatidylcholine
- Kim, Yu.A. (Institute of Cell Biophysics, Russian Academy of Sciences) ;
- Park, Kyeong-Mee (Institute of Cell Biophysics, Russian Academy of Sciences) ;
- Park, Hwa-Jin (Korea Ginseng & Tobacco Research Institute, Department of Biochemical Pharmacology)
- 발행 : 1996.04.01
초록
The effect of ginseng glycosides and their aglycones on the thermodynamic characteristics of membranes from dipalmitoylphosphatidylcholine (DPPC) was investigated. Total saponins (TS) from Korean red ginseng, Panax ginseng C.A. Meyer, interacted with the Eel Phase of lipid in the Polar region and did not penetrate the deeper glycerol backbone of lipid molecule. From the all investigated components of TS (aglycons and ginsenosides), only 20-(S)-panaxadiol (PD) had an effect similar to TS. High concentration of TS penetrated in hydrophobic Cl-C8 region. The presence of cholesterol did not influence the interaction of TS with DPPC. An elimination of transition, however, took place at 10~100