KOREAN JOURNAL OF CROP SCIENCE (한국작물학회지)
- Volume 41 Issue spc1
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- Pages.25-45
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- 1996
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- 0252-9777(pISSN)
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- 2287-8432(eISSN)
Physiological Function of Isoflavones and Their Genetic and Environmental Variations in Soybean
콩 Isoflavone의 생리활성 기능과 함량 변이
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Kim Yong-Ho
(National Corp Experiment Station, RDA) ;
- Kim Seok-Dong (National Corp Experiment Station, RDA) ;
- Hong Eun-Hi (National Corp Experiment Station, RDA) ;
- Ahn Wan-Sik (Agricultural Science and Technology Institute, RDA)
- Published : 1996.03.01
Abstract
Soyfoods have potential roles in the prevention and treatment of chronic diseases, most notably cancer, osteoporosis, and heart disease. There is evidence that carcinogenesis are supressed by isolated soybean derived products in vivo such as a protease inhibitor, phytic acid, saponins and isoflavones. It is believed that supplementation of human diets with soybean products markedly reduces human cancer mortality rates. Especially, recent papers recognize the potential benefit of soybean isoflavone components for reducing the risk of various cancers. Isoflavones exhibit a multitude of medicinal effects that influence cell growth and regulation, which may have potential value in the prevention and treatment of cancer. In addition to potential biological effects, soybean isoflavones have the important physiological functions such as the induction of Bradyrizobium japonicum nod genes and the responses of soybean tissues to infection by Phytophthora megasperma as well as biochemical activities such as antifungal and antibacterial actions. Genistin, daidzin, glycitin and their aglycone (genistein, daidzein, glycitein) are the principal isoflavones found in soybean. Malonyl and acetyl forms have also been detected but they are thermally unstable and are usually transformed during the processing in glucoside form. Most soy products, with the exception of soy sauce, alcohol-extracted soy protein concentrate, and soy protein isolate, have total isoflavone concentrations similar to those in the whole soybean. Soybean-containing diets inhibit mammary tumorigenesis in animal models of breast cancer, therefore, it is possible that dietary isoflavones are an important factor accounting for the lower incidence and mortality from breast cancer. Of the total soybean seed isoflavones,