생약학회지 (Korean Journal of Pharmacognosy)
- 제27권4호
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- Pages.371-377
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
노화 촉진 생쥐에서 녹용의 조혈 작용에 관한 연구
A Study of Hematopoietic Action of Pilose Antler in Senescence Accelerated Mice
- Kim, Yun-Tai (Department of Herbal Medicine, Korea Institute of Oriental Medicine) ;
- Kim, Chung-Sook (Department of Herbal Medicine, Korea Institute of Oriental Medicine)
- 발행 : 1996.12.30
초록
In previous studies we reported that the levels of RBC, hemoglobulin (HGB) and hematocrit (HCT) in SAM P6 were increased significantly from 7 day after oral administration of the pilose antler extract, 5 g/kg/day, and were lasted during the study. Thus, this study was performed to elucidate mechanism of erythropoietic action by the extract administration. SAM R1 and SAM P6 were chosen as experimental animals. At age of 12 weeks, pilose antler extract were given 0.3 and 5 g/kg/day (p.o.) each for 0, 7 and 14 days in both animals. Complete blood cells such as RBC, HGB, and HCT were counted. And plasma concentration of erythropoietin (EPO) which is the major regulator of erythropoiesis was measured using