Korean Journal of Pharmacognosy (생약학회지)
- Volume 27 Issue 1
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- Pages.47-52
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
The Effects of Meliae toosendan Fructus on Liver Function. III. -Effects of Melianone and 28-Deacetyl Sendanin on Drug Metabolism and Bile Juice Secretion-
천련자(川煉子) 성분(成分)이 간기능(肝機能)에 미치는 영향(影響)에 관한 연구(硏究) III. -Melianone과 28-deacetyl sendanin의 약물 대사효소계 및 담즙분비에 미치는 영향-
- Kim, Bu-Saeng (College of Pharmacy, Kyungsung University) ;
- Kim, Hye-Kyung (College of Pharmacy, Kyungsung University) ;
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Choi, Jong-Won
(College of Pharmacy, Kyungsung University)
;
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Lee, Chung-Kyu
(College of Pharmacy, Kyungsung University)
- Published : 1996.03.30
Abstract
A triterpenoid(melianone) and a limonoid(28-deacetyl sendanin) were isolated from the chloroform fraction of Meliae toosendan Fructus, the rippen fruits of Melia toosendan SIEB. et ZUCC.(Meliaceae) and were applied to serial experiments to clarify the liver protective activities. We found that the compounds promoted slightly the drug metabolizing enzyme activities and decreased serum transaminase activities which was elevated by carbon tetrachloride intoxication. And also they slightly increased the secretion of bile juice in rat.