Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Effects of Triterpenoids on Interleukin-8/CINC-1 Induction in LPS-Stimulated Rat Peritoneal Macrophages

  • Min, Bok-Gi (College of Pharmacy, Chungbuk National University) ;
  • Lee, Gyeong-Im (College of Pharmacy, Chungbuk National University) ;
  • Ha, Joo-Young (College of Pharmacy, Chungbuk National University) ;
  • Min, Kyung-Rak (College of Pharmacy, Chungbuk National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Kim, Young-Soo (College of Pharmacy, Chungbuk National University)
  • Published : 1996.06.01
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Abstract

The CINC-1 is a member of rat interleukin-8 with chemotactic and activating properties to neutrophils. The CINC-1 induction in LPS-stimulated rat peritoneal macrophages was analyzed using a sensitive enzyme-linked immunosorbent assay. The peritoneal macrophages contained about 3 ng/ml as a basal level, and induced to maximal 18 ng/ml of CINC-1 by stimulation with 5 ${\mu}g/ml$ of LPS. Antiinflammatory steroids of dexamethasone and triamcinolon significantly suppressed the CINC-1 induction, where as aspirin and idomethacin did not show suppression. Inhibitory effects on the CINC-1 induction by natural triterpenoids having steroidal structures were analyzed. Among the 39 kinds of triterpenoids isolated from herbal medicines, acacigenin B and nigaichigoside F1 exhibited the highest suppression on the CINC-1 induction.

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