BMB Reports

Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Conformation Studies by Circular Dichroism and Fluorescence Spectroscopy of Myelin P2 Protein and Two of its Peptides

  • Shin, Hang-Cheol (Hanhyo Institute of Technology) ;
  • McFarlanel, Ernest F. (School of Chemistry, The University of Sydney)
  • Received : 1995.08.09
  • Published : 1995.11.30
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Abstract

The conformation studies of myelin P2 protein and two of its major peptides were carried out using circular dichroism and fluorescence spectroscopy in water and in lipid environments. Significant conformational changes occur when the protein or peptides were bound to gangliosides. Similar effects were also found in trifluoroethanol solutions. The conformational features of P2 protein and its major peptides were discussed in relation to the environmental changes and the disease-inducing effects.

Keywords

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