Designs for Improving Mean Response

Estimation of each of mean response, difference between mean responses and derivatives of the response function is a possible objective of a response surface design. These objectives are to be achieved simultaneously when an experiment is designed to improve mean response. For the situations where departure from the assumed model is suspected, first and second order designs for improving mean response are obtained by combining minimum bias designs for the individual design objectives. D- and A-optimalities are used for selecting specific second order designs. The results are applied to central composite designs.