Journal of Preventive Medicine and Public Health
- 제28권1호
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- Pages.141-152
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- 1995
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Ethanol이 Trichloroethylene 대사효소의 활성도와 유도성에 미치는 영향
Effects of Ethanol on the Activities and Inducibility of Trichloroethylene Metabolic Enzyme System in Rat Liver
- 김기웅 (한국산업안전공단 산업보건연구원) ;
- 강성규 (한국산업안전공단 산업보건연구원) ;
- 조영숙 (한국산업안전공단 산업보건연구원) ;
- 이세휘 (한국산업안전공단 산업보건연구원) ;
- 문영한 (한국산업안전공단 산업보건연구원) ;
- 최병순 (동국대학교 의과대학) ;
- 박상신 (미국국립암연구소)
- Kim, Ki-Woong (Industrial Health Research institute, KISCO) ;
- Kang, Seung-Kyu (Industrial Health Research institute, KISCO) ;
- Cho, Young-Sook (Industrial Health Research institute, KISCO) ;
- Lee, Sei-Hui (Industrial Health Research institute, KISCO) ;
- Moon, Young-Hahn (Industrial Health Research institute, KISCO) ;
- Choi, Byung-Soon (College of Medicine, Dongguk University) ;
- Park, Sang-Shin (National Cancer Institute, Laboratory of Comparative Carcinogenesis)
- 발행 : 1995.03.01
초록
This study was performed to find out the influences of ethanol on the metabolism of trichloroethylene(TRI) in rats. TRI in corn oil at the dosage of 150, 300, 600 mg/kg was injected peritoneally once a day for two days to two groups. In one group ethanol(4 g/kg) was taken orally 30 minutes before TRI injection, and the other group ethanol was not. The results of experiments are as follows: 1. The contents of cytochrome P-450 and