Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Laserthermia Induced Histological Changes in Different Thermal Condition

Laser Hyperthermia에서 조건변동에 따른 병소변화

  • Kim, Sang-Woo (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Lee, Kyung-Yup (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Seong-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Bae, Jang-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Oh-Lyong (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Choi, Byung-Yearn (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Cho, Soo-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Shin, Hyun-Jin (Department of Biomedical Engineering, Yeungnam University Hospital) ;
  • Lee, Jun-Ha (Department of Biomedical Engineering, Yeungnam University Hospital)
  • 김상우 (영남대학교 의과대학 신경외과학교실) ;
  • 이경엽 (영남대학교 의과대학 신경외과학교실) ;
  • 김성호 (영남대학교 의과대학 신경외과학교실) ;
  • 배장호 (영남대학교 의과대학 신경외과학교실) ;
  • 김오룡 (영남대학교 의과대학 신경외과학교실) ;
  • 최병연 (영남대학교 의과대학 신경외과학교실) ;
  • 조수호 (영남대학교 의과대학 신경외과학교실) ;
  • 신현진 (영남대학교 의과대학 부속병원 생의공학과) ;
  • 이준하 (영남대학교 의과대학 부속병원 생의공학과)
  • Published : 1995.12.30
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Abstract

Laserthermia is a new method of local hyperthermia using fiber optic guided probe with computer controlled Nd-YAG laser system. We used a synthetic sapphire probe and allowed irradiation with contolled low power laser energy (less than 5W), in different thermal condition (temprature: 38.5~50 degrees C) for 10 minutes, in the normal brain tissue of 18 rabbits. In results, the histological changes of brain tissue was variable (myelin condensation, chromatin condensation, nuclear waving and palisading, RBC discoloration, cell necrosis) in microscopic findings after laser irradiation, but changing area was not occured proportionally in thermal condition level. Cell necrosis appears to over 44.5 degrees C and the distance was about 1.25 mm. This study, using computer controlled laserthermia system for interstitial local hyperthermia, may offer many advantages in the experimental treatment and clinical management of tumor. Minimizing normal tissue damage is now being developed.

18마리 가토의 양측 대뇌반구에 laserthemia후 발생하는 조직학적 변화와 온도변화에 따른 변성의 측정결과는 아래와 같다. 주된 조직학적 변화는 chromatin 응축, myelin 응축, 적혈구 탈색, nuclear waving, nuclear palisading과 세포괴사 등이었다. 온도 변화에 따른 변성의 정도는 $44.5^{\circ}C$이상에서 현저하였으며, 비교치 설명후 그 범위도 약 5배(1.25 mm)정도의 변화를 보였다. Laserthermia에 의한 세포괴사는 $47.5^{\circ}C$이상에서부터 현저하게 보였다. 뇌의 심부병소의 정위적 수술시 온도설정 및 병소치료 범위의 예상이 가능하다.

Keywords